Enzyme‐Triggered <scp>l</scp>‐<i>α</i>/<scp>d</scp>‐Peptide Hydrogels as a Long‐Acting Injectable Platform for Systemic Delivery of HIV/AIDS Drugs (Adv. Healthcare Mater. 18/2023)
نویسندگان
چکیده
HIV/AIDS Drugs In article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of short peptide sequence attached to the zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms drug-releasing hydrogel in response phosphatase enzymes present within skin space. Clinically relevant concentrations zidovudine were delivered rat models for 35 days, outlining promise platform improve patient adherence drugs.
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2023
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202370100